STALENTS合作专家：Guy Barry

Guy Barry Curriculum Vitae Jan 2025
Guy Barry
Address: 5/63 Macquarie Street, QLD, 4067, Australia

My vision is developing advanced medical technologies from the leading edge of academic research.
Currently, I am focusing on continuing validation of a highly innovative AI platform technology that
generates RNA therapies for all cancers to allow cheap, non-toxic, personalized treatment for a global
population through combining basic research and start-up companies (e.g., OncoLife Therapeutics).
Skills/Experience
Academic
I have been an innovative scientist for >30 years. Ran my own laboratory (Neurogenomics) for 4+
years (following PhD studies and two post-doc positions), supervised multiple research staff/students,
performed pioneering research (e.g., cancer, bioinformatics, stem cells, mechanistic non-coding RNA)
and published in high quality journals as lead author (e.g., Neuron and Molecular Psychiatry). I
conceptualized, planned, and managed my own research projects for >15 years investigating
revolutionary conceptual ideas in cancer and stem cell biology.
Biotech/Entrepreneur
I worked as a research scientist for 9 years at an early-stage biotech company in San Diego, California
(Neurocrine Biosciences Inc.) and have recently been CEO at OncoLife Therapeutics, a start-up biotech
company based in Australia and Magnaetus Therapeutics, a start-up based in the UK. These experiences
have led to a deep understanding of early-stage biotech ventures from both scientific and business aspects
and will lead to successful commercialization of my basic scientific research.
Areas of Expertise

• Science/healthspan/genetics
  o Cancer (e.g., glioblastoma, medulloblastoma, non-toxic target discovery)
  o RNA (e.g., mRNA, non-coding RNA, siRNA, miRNA)
  o Bioinformatics (e.g., RNA sequencing, single cell sequencing, proteomics)
  o Metabolism (e.g., peptides, mTOR, pAKT, type 2 diabetes)
  o Stem cells (e.g., hematopoietic, mesenchymal, quiescent)
  o iPS cells/organoids (e.g., neural networks, schizophrenia)
  o Mental health (e.g., schizophrenia, Alzheimer’s disease, epilepsy)
• Healthcare/medical/technology
  o Start-ups
  o Business evaluation
  o Intellectual property o
  Market evaluation
  o New product evaluation
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  Guy Barry Curriculum Vitae Jan 2025
  Tertiary qualifications
  Year Qualification Institution
  2002-2006 Doctor of Philosophy The University of Queensland
  (Conferred October 2006)
  1988-1991 Bachelor of Science, The University of Cape Town
  Microbiology South Africa
  Career chronology
  Year Position Institution
  Aug 2024 – current Manager, Partnerships and QUBIC, UQ
  Translation
  Mar 2020 – current CEO OncoLife Therapeutics
  Jan 2023 – current CEO Magnaetus Therapeutics
  July 2022 – Mar 2024 Entrepreneurial Program AIBN, UQ
  Consultant
  Aug 2021 – June 2023 Research Grant Advisor The GrantEd Group
  Feb 2016 – Jan 2020 Team Head QIMR Berghofer Medical Research
  Institute, Brisbane, Australia
  Aug 2014 – Dec 2015 Group Leader Garvan Institute of Medical
  Research, Sydney, NSW
  July 2012 – current Senior Research Officer
  Garvan Institute of Medical
  Research, Sydney, NSW
  Mar 2011 – June 2012 Associate professor
  The Institute for Molecular
  Bioscience, The University of
  Queensland
  Jan 2007 – Feb 2011 Post-doctoral researcher The Queensland Brain Institute, The
  University of Queensland
  June 2006 – current Associate professor The Queensland Brain Institute, The
  University of Queensland
  June 1993 – current Research Scientist Professor Neurocrine Biosciences Inc.
  San Diego, USA
  April 1992 – May 1993 Research assistant The Scripps Research Institute
  San Diego, USA
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  Guy Barry Curriculum Vitae Jan 2025
  List of Publications

1. Hayley F North, Christin Weissleder, Maina Bitar, Guy Barry, Janice M Fullerton, Maree J
   Webster, Cynthia Shannon Weickert. RNA-sequencing suggests extracellular matrix and
   vasculature dysregulation could impair neurogenesis in schizophrenia cases with elevated
   inflammation (2024) Schizophrenia May 4;10(1):50
2. Maina Bitar, Christin Weissleder, Hayley North, Oressia Zalucki, Michael Piper, Cynthia Shannon
   Weickert, Guy Barry. Identifying gene expression profiles associated with neurogenesis and
   inflammation in the human subependymal zone from development through aging (2022) Scientific
   Reports Jan 7;12(1):40
3. Christin Weissleder, Hayley F. North, Maina Bitar, Janice M. Fullerton, Rachel Sager, Guy Barry,
   Michael Piper, Glenda M. Halliday, Maree J. Webster, Cynthia Shannon Weickert. Reduced Adult
   Neurogenesis is Associated with Increased Macrophages in the Subependymal Zone in
   Schizophrenia (2021) Molecular Psychiatry Nov;26(11):6880-6895
4. Christin Weissleder, Maree J. Webster, Guy Barry, Cynthia Shannon Weickert. Reduced Insulin￾Like Growth Factor Family Member Expression Predicts Neurogenesis Marker Expression in the
   Subependymal Zone in Schizophrenia and Bipolar Disorder (2020) Schizophrenia Bulletin
   (PMID: 33274367)
5. O’Brien E, Ensbey ES, Day BW, Baldock PA, Barry G. Direct Evidence for Transport of RNA From
   the Mouse Brain to the Germline and Offspring (2020) BMC Biology Apr 30;18(1):45.
6. Bitar M, Barry G. Building a human brain for research (2020) Frontiers in Molecular Neuroscience
   Feb 18;13:22.
7. Bitar M; Kuiper S; O’Brien EA; Barry G. Genes with human-specific features are primarily involved
   with brain, immune and metabolic evolution. BMC Bioinformatics Nov 22;20(Suppl 9):406
8. Weissleder C, Barry G, Fung SJ, Wong MW, Double KL, Webster MJ, Weickert CS. Reduction
   in IGF1 mRNA in the Human Subependymal Zone During Aging. (2019) Aging and Disease (*Co￾first authors)
9. Mladenova D, Barry G, Konen LM, Pineda SS, Guennewig B, Avesson L, Zinn R, Schonrock
   N, Bitar M, Jonkhout N, Crumlish L, Kaczorowski DC, Gong A, Pinese M, Franco GR, Walkley C,
   Vissel B and Mattick JS. Adar3 is involved in learning and memory in mice. (2018) Frontiers in
   Neuroscience 13; 12:243.
10. Fernandes DP, Bitar M, Jacobs FMJ, Barry G. (2018) Long non-coding RNAs in neuronal aging.
    Non-Coding RNA 4(2).
11. Barry G. Small RNAs and transposable elements are key components in the control of adaptive
    evolution in eukaryotes. BioEssays (Accepted 19/04/2018)
12. Guennewig B, Bitar M, Obiorah I, Hanks J, O’Brien EA, Kaczorowski DC, Hurd YL, Roussos P,
    Brennand KJ, Barry G (2018) THC exposure of human iPSC neurons impacts genes associated
    with neuropsychiatric disorders Translational Psychiatry 8(1):89
13. Bitar M and Barry G (2018) Multiple innovations in genetic and epigenetic mechanisms cooperate
    to underpin human brain evolution. Molecular Biology and Evolution 35(2):263-268.
14. Bitar M, Kuiper S, O’Brien E, Barry G (2017) Using human iPSC-derived neurons to uncover
    activity-dependent non-coding RNAs. Genes 8(12) (IF 3.6)
15. Barry G, Briggs JA, Hwang DW, Dachet F, Maag JLV, Mestdagh P, Singh EM, Avesson L,
    Kaczorowski DC, Ozturk E, Jones NC, Nayler SP, Fortuna PRJ, Vetter I, Arriola-Martinez L, Hu J,
    Franco GR, Warn VM, Gong A, Dinger ME, Rigo F, Lipovich L, Morris MJ, O’Brien TJ, Lee DS,
    Loeb JA, Blackshaw S, Mattick JS and Wolvetang EJ (2017) The long non-coding RNA NEAT1
    modulates neuronal excitability. Scientific Reports 7:40127 (IF 5.228)
16. Weissleder C, Fung SJ, Wong MW, Barry G, Double KL, Halliday GM, Webster MJ, Shannon
    Weickert C (2016) Decline in proliferation and immature neuron markers in the human
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    Guy Barry Curriculum Vitae Jan 2025
    subependymal zone during aging: Relationship to EGF- and FGF-related transcripts. Frontiers in
    Aging Neuroscience 25;8:274 (IF 4.34)
17. Roussos P, Guennewig B, Kaczorowski DC, Barry G, Brennand KJ (2016) Schizophrenia hiPSC
    neurons display expression changes that are enriched for disease risk variants and a blunted
    activity-dependent response. JAMA Psychiatry 73(11):1180-1188 *Co-last authors (IF 14.4)
18. Barry G (2016) Has inheritance gone retro? Bioessays 38(8):716 (IF 4.73)
19. Stringer BW, Bunt J, Day BW, Barry G, Jamieson PR, Ensbey KS, Bruce ZC, Goasdoué K, Vidal
    H, Charmsez S, Smith FM, Cooper LT, Piper, M Boyd AW, Richards LJ (2016) Nuclear Factor
    One B (NFIB) encodes a subtype-specific tumour suppressor in glioblastoma. Oncotarget
    17;7(20):29306-20 (IF 6.359)
20. Briggs JA, Wolvetang EJ, Mattick JS, Rinn JL and Barry G (2015) Mechanisms of long non￾coding RNAs in mammalian nervous system development, plasticity, disease, and evolution.
    Neuron 88(5): 861-77 (IF 13.974)
21. Barry G, Guennewig B, Fung SJ, Kaczorowski D and Shannon Weickert C (2015) Long non￾coding RNA expression during aging in the human subependymal zone. Frontiers in Neurology
    6:45 (IF 3.184)
22. Barry G, Briggs JA, Vanichkina DP, Poth EM, Beveridge NJ, Ratnu VS, Nayler SP, Nones K, Hu
    J, Bredy TW, Nakagawa S, Rigo F, Taft RJ, Cairns MJ, Blackshaw S, Wolvetang EJ, Mattick JS.
    (2014) The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation
    and involved in schizophrenia-associated alternative splicing. Molecular Psychiatry 19(4): 486-94
    (IF 13.314)
23. Barry G (2014) Integrating the roles of long and small non-coding RNA in brain function and
    disease. Molecular Psychiatry 19(4): 410-6 (IF 13.314)
24. Avesson L, Barry G. (2014) The emerging role of RNA and DNA editing in cancer. Biochim
    Biophys Acta. 1845(2): 308-316 (IF 7.841)
25. Piper M *, Barry G *, Harvey TJ, McLeay R, Smith AG, Harris L, Mason S, Stringer BW, Day
    BW, Wray NR, Gronostajski RM, Bailey TL, Boyd AW, and Richards LJ. (2014) NFIB-mediated
    repression of the epigenetic factor Ezh2 regulates cortical development. Journal of Neuroscience
    34(8): 2921-30 *Co-first authors (IF 6.92)
26. Heng YH, McLeay RC, Harvey TJ, Smith AG, Barry G, Cato K, Plachez C, Little E, Mason S,
    Dixon C, Gronostajski RM, Bailey TL, Richards LJ, Piper M. (2014) NFIX Regulates Neural
    Progenitor Cell Differentiation During Hippocampal Morphogenesis. Cerebral Cortex 24(1): 261-79
    (IF 8.285)
27. Barry G (2013) Lamarckian evolution explains human brain evolution and psychiatric disorders.
    Frontiers in Neuroscience. 7:224. (IF 3.398)
28. Barry G, Mattick JS (2012) The role of regulatory RNA in cognitive evolution. Trends in Cognitive
    Sciences 16(10): 497-503. (IF 17.850)
29. Heng YH, Barry G, Richards LJ, Piper M (2012) Nuclear Factor I Genes Regulate Neuronal
    Migration. Neurosignals 20(3): 159-67 (IF 1.592)
30. Piper M, Harris L, Barry G, Heng YH, Plachez C, Gronostajski RM, Richards LJ. (2011) Nuclear
    factor one X regulates the development of multiple cellular populations in the postnatal
    cerebellum. J Comp Neurol. 519(17): 3532-48
31. Piper M, Barry G, Hawkins J, Mason S, Lindwall C, Little E, Sarkar A, Smith AG, Moldrich RX,
    Boyle GM, Tole S, Gronostajski RM, Bailey TL, Richards LJ (2010) NFIA controls telencephalic
    progenitor cell differentiation through repression of the Notch effector Hes1. Journal of
    Neuroscience 30:9127-39 *Co-first authors
32. Piper M, Moldrich RX, Lindwall C, Little E, Barry G, Mason S, Sunn N, Kurniawan ND,
    Gronostajski RM, Richards LJ. (2009) Multiple non-cell-autonomous defects underlie neocortical
    callosal dysgenesis in Nfib-deficient mice. Neural Development 4; 4(1): 43
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    Guy Barry Curriculum Vitae Jan 2025
33. Barry G, Piper M, Lindwall C, Moldrich R, Mason S, Little E, Sarkar A, Tole S, Gronostajski RM,
    Richards LJ (2008) Specific glial populations regulate hippocampal morphogenesis. Journal of
    Neuroscience 28:12328-40.
34. Barry G, Ross IL (2008) Neurosteroids and sporadic Alzheimer’s disease. Current Alzheimer
    Research 5: 267-374
35. Piper M, Dawson AL, Lindwall C, Barry G, Plachez C, Richards LJ (2007) Emx and Nfi genes
    regulate cortical development and axon guidance in the telencephalon. Novartis Foundation
    Symposium 288: 276-81. Review.
36. Schwarz DA, Barry G, Mackay KB, Manu F, Naeve GS, Vana AM, Verge G, Conlon PJ, Foster
    AC, Maki RA (2002) Identification of differentially expressed genes induced by transient ischemic
    stroke. Brain Research. Molecular Brain Research 101:12-22.
37. Schwarz DA, Barry G, Eliasof SD, Petroski RE, Conlon PJ, Maki RA. (2000) Characterization of g￾aminobutyric acid receptor GABAB(1e), a GABAB(1) splice variant encoding a truncated receptor.
    Journal of Biological Chemistry 275:32174-81.
38. Liu C, Liu XJ, Crowe PD, Kelner GS, Fan J, Barry G, Manu F, Ling N, De Souza EB, Maki RA.
    (1999) Nephroblastoma overexpressed gene (NOV) codes for a growth factor that induces protein
    tyrosine phosphorylation. Gene 238:471-8.
39. Liu C, Liu XJ, Barry G, Ling N, Maki RA, De Souza EB (1997) Expression and characterization of
    a putative high affinity human soluble leptin receptor. Endocrinology 138:3548-54.
40. Liaw CW, Lovenberg TW, Barry G, Oltersdorf T, Grigoriadis DE, de Souza EB. (1996) Cloning and
    characterization of the human corticotropin-releasing factor-2 receptor complementary
    deoxyribonucleic acid. Endocrinology 137:72-7.
    Contribution to research training
    Lecturing

• Lecturer, Stem Cells and Regenerative Medicine (DEVB3002), The University of
  Queensland (2019, 2020)
• Lecturer, Molecular Genomics (BABS3281), School of Biotechnology and Biomolecular
  Sciences, Faculty of Science, University of New South Wales (2014)
• Lecturer, Bachelor/Master of Biotechnology (BIOT2002/6006), School of Chemistry &
  Molecular Biosciences, The University of Queensland (2010-2012)
• Problem-based Learning (PBL) Tutor, Foundations of Medical Practice (MEDI1000), The
  University of Queensland (2010-2013)
  Supervision
• Co-Supervisor, Masters student (Diana Pereira Fernandes) 2017-present, University of
  Amsterdam
• Supervisor, Honours student (Stefanie Kuiper) 2017, Griffith University
• Supervisor, WILS placement, Bachelor of Biomedical Science (Emily Bergmann)
  2017, Queensland University of Technology (27/2/17 – 2/6/17)
• Supervisor, Honours student (Andrew Gong) 2015, University of New South Wales
• Co-supervisor, Honours student (Lakshini Ranganathan) 2014, University of New South
  Wales (Beverdam laboratory)
• Co-supervisor, PhD students (Ganqiang Liu 2011-2015; Luis Arriola 2013-present), Garvan
  Institute of Medical Research, University of New South Wales
• Supervisor, Undergraduate Research Opportunity Program (UROP) student 2014 (Victoria
  Warn, University of Technology Sydney), Garvan Institute of Medical Research, University of
  New South Wales
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  Guy Barry Curriculum Vitae Jan 2025
• Co-Supervisor, Honours students (Lauren Crumlish, James Briggs), 2012, The University of
  Queensland
  Successful grant applications
• Perpetual 2017 IMPACT Philanthropy Application Program, 2017, (IPAP2017/164), Is
  Schizophrenia Brain Diabetes? $183,638.00.
• John Templeton Foundation, 2017, (60648) Heritability is not random: Evidence for a mechanism
  of heritable somatic cell adaptations, $196,000.00.
• Rebecca L Cooper Medical Research Foundation, 2017 Medical Research Grant, ‘Brain Diabetes’,
  Dr Guy Barry, $23,000.00.
• CIB, Australian Research Council Discovery Grant 2015, DP150104168, Enhancing neurogenesis
  in the adult primate brain, Prof Cynthia Shannon Weickert, Dr Guy Barry, Dr Samantha Fung,
  $383,471.00.
• Rebecca L Cooper Medical Research Foundation, 2014 Medical Research Grant, ‘Modulation of
  gene expression in human neurons derived from patients’, Prof John Mattick, Dr Guy Barry, A/Prof
  Antony Cooper, Dr Daniel Hesselson, Prof Carolyn Sue, Dr Bryce Vissel.
• CIC, NHMRC Project grant, 2013 (APP1043023), ‘Investigation of processed snoRNAs as cryptic
  regulators of the imprinted Prader-Willi syndrome locus’, $650,802.26.
  Awards
• InnoCentive Challenge award; April 20th 2015 ($5,000; InnoCentive 9933446 – ‘Novel Treatment
  Approaches to Cure Inflammatory Bowel Diseases’. This stems from work undertaken during my
  PhD studies investigating Crohn’s disease.
• Young Garvan Award (Finalist) 2014: Awarded $10,000 for research
• The Society for Neuroscience Chapters Postdoctoral Trainee Travel Award 2008, Neuroscience
  2008, November, Washington, DC.
• The Bill Evans Memorial Young Investigator Award, The Australian and New Zealand Society for
  Neuropathology, 28th Annual Scientific Meeting, May 24th 2008, Royal Brisbane Hospital, Brisbane
  Invited International Oral Presentations
• 21st Evolutionary Biology Meeting, Marseilles, France, September 26-29,
  2017 Title: Mechanisms underpinning the evolution of the human brain
• Genetica 2017 – 63rd Brazilian-International Congress of Genetics September 12-17, 2017
  Title: Mechanisms underpinning the evolution of the human brain
• International Congress on Schizophrenia Research, April 21-25, 2013, Florida, USA
  Title: ‘The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation
  and involved in schizophrenia-associated alternative splicing’
  Invited Local Oral Presentations
• 38th Annual Scientific Meeting of the Australasian Neuroscience Society, 3rd
  -6
  th December
  2018, Brisbane, QLD
• Better Health through Bio-Chemistry (One day public conference) Surfers Paradise, QLD, 2nd
  April 2017
• Society for Molecular Biology and Evolution Annual Meeting, Gold Coast Convention &
  Exhibition Centre, Queensland, Australia, July 3rd
  -7
  th 2016.
• Combio2015, Melbourne Convention and Exhibition Centre, Sept 27th
  -Oct 1st 2015.
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  Guy Barry Curriculum Vitae Jan 2025
• Queensland Institute of Medical Research, Institute Seminar, August 10th 2015, Brisbane
• School of Biomedical Sciences Seminar Series, The University of Queensland, August 8, 2014
  Peer Review (Journals- Selected)
• Molecular Psychiatry
• Nature Communications
• Translational Psychiatry
• BioEssays
• Scientific Reports
• Biological Psychiatry
• Schizophrenia Research
  Peer Review (Grants)
• ARC 2019 (External grant assessor) Discovery Project (x1)
• ARC 2018 (External grant assessor) Both DECRA (x1) and Discovery Project (x1)
• The MND Association, UK (External Assessor, Fellowship Grant Application) 2017
• NHMRC 2010-2018 (External grant assessor)
• ARC 2016 (External grant assessor) Both DECRA (x1) and Discovery Projects (x2)
• Cancer Research UK: New Investigator Committee – CDF 2015 (External Assessor)
• Women’s and Children’s Health Network Research Project Grant 2014 (External Assessor)
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